TRANSCRANIAL BRAIN IMAGING (STUDY THE EFFECT OF SKULL)

Skull bone represents a highly acoustical impedance mismatch and a dispersive barrier for the propagation of acoustic waves. Skull distorts the amplitude and phase information of the received waves at different frequencies in a transcranial brain imaging. We have studied the effect of the skull on the photoacoustic image formation in both the illumination path and acoustic propagation path separately and combined. We have developed algorithms for the compensation of the skull-induced distortions in transcranial photoacoustic tomography and microscopy. These algorithms have been tested on tissue phantoms and large animal skull tissues.

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