As with other imaging modalities that employ coherent detection, OCT images are confounded by speckle noise. Another major issue in imaging is the loss of signal within the tissue, which results in a weak backscattered signal from deeper layers. There are several explanations for the loss of signal with imaging depth, such as optical properties of the imaged object (scattering and absorption) and defocusing of the imaging beam. Another issue is OCT image blurriness which is due to the imperfection of the optical devices used in the configuration of the OCT device.  We have devised signal/image processing methods to reduce the effect of speckle for better visibility of the diagnostically important information in the images, algorithms to compensate for the intensity decay, and deconvolution-based algorithms to deal with image blurriness.

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